个人护理品（PCPs）中遮光剂系列成分的生态毒性和潜在风险评价

论文总字数：30250字

摘 要

结果如下：

1、BP-1对普通小球藻的生长具有显著的抑制作用，96h急性毒性属于中毒。对大型溞显示出致死毒性， 48小时急性毒性属于中毒。

2、BP-2对普通小球藻的生长具有显著的抑制作用，96h急性毒性属于中毒。BP-2对大型溞显示出致死毒性， 48小时急性毒性属于中毒。

3、BP-1和BP-2混合物对小球藻的复合毒性表现为加和作用；BP-1和BP-3混合物对小球藻的复合毒性表现为拮抗作用；BP-1、BP-3和BP-4混合液对小球藻的复合毒性表现为拮抗作用；BP-1、BP-2、BP-3和BP-4混合液对小球藻的复合毒性表现为拮抗作用。

4、通过BP-1与BP-2对普通小球藻与大型溞的急性毒性试验结果，进行生态风险评价。使用评估因子法（AF）计算出的BP-1的预测无效应浓度值(PNEC)为0.00174mg/L；BP-2的PNEC值为0.00528mg/L。仍属于对生态环境风险较低的一类物质。

关键词：个人护理品；遮光剂；急性毒性；生态风险评价

Ecological toxicity and potential risk assessment of sunscreen chemicals in personal care products (PCPs)

03213713 Cui Xinyu

Supervised by Liwei Sun

Abstract：With the improvement of living standards and lifestyle changes, the types and quantities of personal care products will continue to increase, and will continue to be discharged to the environment because of production, transportation and consumption. Although the personal care products has been detected in various environmental media and even the human body,. Therefore, it is very important to explore the ecological toxicity of personal care products in aquatic organisms. Chlorella vulgaris and Daphnia magna were employed as testing organisms according to the standard methods, the acute single and mixed toxicity of 2,4-dihydroxybenzophenone (BP-1), 2,2 ', 4,4'-tetrahydroxybenzophenone (BP-2) were evaluated . We also conducted a mixed toxicity evaluation test for BP-1 amp; BP-3, BP-1, BP-3 amp; BP-4, BP-1, BP-2, BP-3 amp; BP-4. These chemicals are important members of sunscreens in personal care products to protect hair skin from UV rays. The results are as follows:

1, BP-1 had a significant inhibitory effect on the growth of C. vulgaris, The toxicity of BP-1 to C. vulgaris.was judged as moderate. BP-1 showed a lethal toxicity to D. magna, The toxicity of BP-1 to D. magna was judged as moderate.

2, BP-2 had a significant inhibitory effect on the growth of C. vulgaris, The toxicity of BP-2 to C. vulgaris.was judged as moderate. BP-2 showed a lethal toxicity to D. magna, The toxicity of BP-2 to D. magna was judged as moderate.

3, The mixture of BP-1 and BP-2 showed synergistic effect to C. vulgaris;the mixture of BP-1 and BP-3 were antagonistic to C. vulgaris; the mixture of BP-1, BP-3 and BP-4 were antagonistic C. vulgaris;the mixture of BP-1, BP-2, BP-3 and BP-4 are antagonistic toC. vulgaris;

4 Based on the acute toxicity test data of BP-1 and BP-2, the ecological risk assessment was carried out using the evaluation factor method (AF). The predicted non-effect concentration (PNEC) of BP-1 was 0.00191 mg / L; the PNEC value of BP-2 was 0.00192 mg / L，Still belong to the lower risk of ecological environment of a class of substances.

Key words：PCPs；sunscreen；acute toxicity；ecological risk assessment

目录

1、绪论 8

1.1 研究背景 8

1.2 国内外对PCPs生态毒性研究的现状 8

1.3 遮光剂成分简介 9

1.4 环境中的遮光剂成分 9

1.5 遮光剂成分的生态毒性 10

1.6 研究的目的与意义 11

2、实验材料与方法 12

2.1被评价的化学物质 12

2.1.1 实验中使用的化学品 12

2.1.2药品性质 12

2.2 毒性实验对象 14

2.2.1 供试绿藻 14

2.3 急性毒性试验原理和方法 14

2.3.1 急性毒性试验原理 14

2.3.2 小球藻急性毒性试验方法 14

2.3.3 大型溞急性毒性实验方法 17

2.3.4 复合毒性的评价 17

3、实验结果 19

3.1 2,4-二羟二苯甲酮（BP-1） 19

3.1.1 BP-1对小球藻急性毒性 19

3.1.2 BP-1对大型溞的急性毒性 20

3.2 2,2',4,4'-四羟基二苯甲酮(BP-2) 21

3.2.1 BP-2对小球藻的急性毒性 21

3.2.2 BP-2对大型溞的急性毒性 22

3.3复合毒性 23

3.3.1 BP-1与BP-2混合液对小球藻的复合毒性 23

3.3.2 BP-1与BP-3混合液对小球藻的复合毒性 24

3.3.3 BP-1、BP-3与BP-4混合液对小球藻的复合毒性 25

3.3.4 BP-1、BP-2、BP-3与BP-4混合液对小球藻的复合毒性 27

4、生态风险评价与分析 29

4.1 BP-1急性毒性结果的生态风险评价与分析 29

4.2 BP-2急性毒性结果的生态风险评价与分析 29

5、结语 31

5.1遮光剂系列物质急性毒性实验结论 31

5.2遮光剂系列物质急性毒性结果的生态风险评价结论 32

5.3展望 32

参考文献： 34

致 谢 38

个人护理品(PCPs)中遮光剂系列成分的生态毒性

和潜在风险评价

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